Weakened tanning ability is an important mechanism for evolutionary skin lightening in East Asians.

doi:10.1016/j.jgg.2024.03.001

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Article

Weakened tanning ability is an important mechanism for evolutionary skin lightening in East Asians.

Journal of genetics and genomics = Yi chuan xue bao - 1 Jul 2024

Pu Youwei, Pu Siyu, Chen Yanyan, Kong Qinghong, Liu Xuyang, Zhao Qi, Xu Ke, Liu Jiuming, Li Mengyuan, Xu Xiaoyu, Qiao Xiaoyang, Su Bing, Chen Jing, Yang Zhaohui

Abstract excerpt

The evolution of light-skin pigmentation among Eurasians is considered as an adaptation to the high-latitude environments. East Asians are ideal populations for studying skin color evolution because of the complex environment of East Asia. Here, we report a strong selection signal for the pigmentation gene phenylalanine hydroxylase (PAH) in light-skinned Han Chinese individuals. The intron mutation rs10778203 in...

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Identifiers

PMID: 38461943
DOI: 10.1016/j.jgg.2024.03.001

Genes

PAH
SMAD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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