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The genetic architecture of human skin pigmentation: evolution and adaptation across global populations

23 Jul 2026

Abstract excerpt

Human skin pigmentation is a dynamic and highly adaptive trait influenced by genetic, environmental, and cultural factors. It is driven by variation in ultraviolet radiation, governed by a complex polygenic structure, and further modulated through gene-culture interactions. This review synthesizes advances from evolutionary biology, anthropology, molecular genetics, and gene-culture coevolution to provide an...

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PMID: 42565097
DOI: 10.3389/fgene.2026.1870791

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