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Article

Are Next-Generation Pathogenicity Predictors Applicable to Cancer?

Journal of molecular biology - 15 Aug 2024

Ostroverkhova Daria, Sheng Yiru, Panchenko Anna

Abstract excerpt

Next-generation pathogenicity predictors are designed to identify pathogenic mutations in genetic disorders but are increasingly used to detect driver mutations in cancer. Despite this, their suitability for cancer is not fully established. Here we have assessed the effectiveness of next-generation pathogenicity predictors when applied to cancer by using a comprehensive experimental benchmark of cancer driver and...

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Identifiers

PMID: 38848867
DOI: 10.1016/j.jmb.2024.168644

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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