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Measuring the Efficiency of Purging by non-random Mating in Human Populations.

Molecular biology and evolution - 1 Jun 2024

Laurent Romain, Gineau Laure, Utge José, Lafosse Sophie, Phoeung Chan Leakhena, Hegay Tatyana, Olaso Robert, Boland Anne, Deleuze Jean-François, Toupance Bruno, Heyer Evelyne, Leutenegger Anne-Louise, Chaix Raphaëlle

Abstract excerpt

Human populations harbor a high concentration of deleterious genetic variants. Here, we tested the hypothesis that non-random mating practices affect the distribution of these variants, through exposure in the homozygous state, leading to their purging from the population gene pool. To do so, we produced whole-genome sequencing data for two pairs of Asian populations exhibiting different alliance rules and rates...

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Identifiers

PMID: 38839045
DOI: 10.1093/molbev/msae094
PMCID: PMC11184347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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