Article

Sequence architecture shapes human allele frequencies through ectopic gene conversion

2026-08-28

Abstract excerpt

Population-genetic interpretations of allele frequency commonly begin from a single-origin assumption: that a variant arose once and was subsequently shaped by selection, drift and demographic history. Here we show that for a substantial fraction of human variation this assumption fails, and fails predictably: ectopic gene conversion reintroduces the same nucleotide change generation after generation, at rates str...

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Literature Corpus work: eaadbe8f-1603-5f93-8a1b-653a758e3f95
DOI: 10.64898/2026.08.26.747289

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