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Article

HIV-1 Gag Compact form Stabilized by Intramolecular Interactions is Crucial for Infectious Particle Production.

Journal of molecular biology - 15 Aug 2024

Zeiger Manon, Pires Manuel, Didier Pascal, Vauchelles Romain, Mély Yves, Boutant Emmanuel, Real Eléonore

Abstract excerpt

HIV-1 Gag polyprotein plays a pivotal role in assembly and budding of new particles, by specifically packaging two copies of viral gRNA in the host cell cytoplasm and selecting the cell plasma membrane for budding. Both gRNA and membrane selections are thought to be mediated by the compact form of Gag. This compact form binds to gRNA through both its matrix (MA) and nucleocapsid (NC) domains in the cytoplasm. At...

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Identifiers

PMID: 38838849
DOI: 10.1016/j.jmb.2024.168639

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