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APOBEC3G Impairs the Multimerization of the HIV-1 Vif Protein in Living Cells

10 Apr 2013

Abstract excerpt

The HIV-1 viral infectivity factor (Vif) is a small basic protein essential for viral fitness and pathogenicity. Vif allows productive infection in nonpermissive cells, including most natural HIV-1 target cells, by counteracting the cellular cytosine deaminases APOBEC3G (apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G [A3G]) and A3F. Vif is also associated with the viral assembly complex and...

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PMID: 23576497
DOI: 10.1128/jvi.03494-12

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