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Chemical Proteomic Profiling of Protein Dopaminylation in Colorectal Cancer Cells

5 Jun 2024

Abstract excerpt

Histone dopaminylation is a newly identified epigenetic mark that plays a role in the regulation of gene transcription, where an isopeptide bond is formed between the fifth amino acid of H3 (i.e., glutamine) and dopamine. Recently, we developed a chemical probe to specifically label and enrich histone dopaminylation via bioorthogonal chemistry. Given this powerful tool, we found that histone H3 glutamine 5...

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PMID: 38838187
DOI: 10.1021/acs.jproteome.4c00379

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