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yQTL Pipeline: A structured computational workflow for large scale quantitative trait loci discovery and downstream visualization.

PloS one - 1 Jan 2024

Li Mengze, Song Zeyuan, Gurinovich Anastasia, Schork Nicholas, Sebastiani Paola, Monti Stefano

Abstract excerpt

Quantitative trait loci (QTL) denote regions of DNA whose variation is associated with variations in quantitative traits. QTL discovery is a powerful approach to understand how changes in molecular and clinical phenotypes may be related to DNA sequence changes. However, QTL discovery analysis encompasses multiple analytical steps and the processing of multiple input files, which can be laborious, error prone, and...

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PMID: 38833463
DOI: 10.1371/journal.pone.0298501
PMCID: PMC11149833

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