Article
Association of partial T2-FLAIR mismatch sign and isocitrate dehydrogenase mutation in WHO grade 4 gliomas: results from the ReSPOND consortium.
Neuroradiology - 1 Sept 2023
Lee Matthew D, Patel Sohil H, Mohan Suyash, Akbari Hamed, Bakas Spyridon, Nasrallah MacLean P, Calabrese Evan, Rudie Jeffrey, Villanueva-Meyer Javier, LaMontagne Pamela, Marcus Daniel S, Colen Rivka R, Balana Carmen, Choi Yoon Seong, Badve Chaitra, Barnholtz-Sloan Jill S, Sloan Andrew E, Booth Thomas C, Palmer Joshua D, Dicker Adam P, Flanders Adam E, Shi Wenyin, Griffith Brent, Poisson Laila M, Chakravarti Arnab, Mahajan Abhishek, Chang Susan, Orringer Daniel, Davatzikos Christos, Jain Rajan
Abstract excerpt
PURPOSE: While the T2-FLAIR mismatch sign is highly specific for isocitrate dehydrogenase (IDH)-mutant, 1p/19q-noncodeleted astrocytomas among lower-grade gliomas, its utility in WHO grade 4 gliomas is not well-studied. We derived the partial T2-FLAIR mismatch sign as an imaging biomarker for IDH mutation in WHO grade 4 gliomas. METHODS: Preoperative MRI scans of adult WHO grade 4 glioma patients (n = 2165) from...
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