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Article

p53 as a Potential Actionable Target in Myxofibrosarcoma: A Molecular and Pathologic Review of a Single-Institute Series.

Laboratory investigation; a journal of technical methods and pathology - 1 Aug 2024

Laranga Roberta, Pazzaglia Laura, Pedrini Elena, Sambri Andrea, Ferrari Cristina, Locatelli Manuela, Sangiorgi Luca, Righi Alberto, Scotlandi Katia, Bianchi Giuseppe

Abstract excerpt

Myxofibrosarcoma (MFS) is a common adult soft tissue sarcoma characterized by high-local recurrence rate, poorly understood molecular pathogenesis, lack of specific prognostic markers, and effective targeted therapies. To gain further insights into the disease, we analyzed a well-defined group of 133 primary MFS cases. Immunohistochemical (IHC) staining for p53, MET, RET, and RB was performed. Twenty-five cases...

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Identifiers

PMID: 38825319
DOI: 10.1016/j.labinv.2024.102088

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