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Lipid traits and lipid-lowering drug target genes and risk of melanoma: a mendelian randomization study.

Archives of dermatological research - 31 May 2024

Che Yuhui, Yuan Jinyao, Tang Dadong, Guo Jing

Abstract excerpt

Our study aimed to investigate the role of lipids in melanoma risk and the effect of lipid-lowering drug targets on melanoma. Using Mendelian Randomization analysis, we examined the genetic agents of nine lipid-lowering drugs and their association with melanoma risk. We found that genetically proxied inhibition of HMGCR, ABCG5/ABCG8, and ANGPTL3 was associated with a reduced risk of melanoma. On the other hand,...

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PMID: 38819656
DOI: 10.1007/s00403-024-03100-2

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