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PKM2 Facilitates Classical Swine Fever Virus Replication by Enhancing NS5B Polymerase Function

29 Apr 2025

Abstract excerpt

Host metabolic reprogramming is a critical strategy employed by many viruses to support their replication, and the key metabolic enzyme plays important roles in virus infection. This study investigates the role of pyruvate kinase M2 (PKM2), a glycolytic enzyme with non-canonical functions, in the replication of classical swine fever virus (CSFV). Using PK-15 cells and piglet models, we demonstrate that CSFV...

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PMID: 40431660
DOI: 10.3390/v17050648

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