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Article

Integrating genomic structural equation modeling and experimental validation to unravel the genetic basis of male genital lichen sclerosus.

Frontiers in immunology - 1 Jan 2026

Chen Jianbai, Zhang Zhiming, Fu Qiang, Hou Haozhong, Xu Gongquan, Li Zhenyu, Lu Zhiguo, Qiu Jianxin, Wu Ke, Gao Xiaoping, Zhang Geng, Yang Longfei, Song Rundong, Zhang Wei

Abstract excerpt

Objective: To investigate the genetic architecture of male genital lichen sclerosus (MGLSc) and to identify potential susceptibility loci, candidate genes, and biological pathways associated with disease pathogenesis by integrating genomic structural equation modeling (Genomic-SEM) with multi-omics analyses and experimental validation. Methods: Publicly available genome-wide association study (GWAS) summary...

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Share to BTNL2 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42553536
DOI: 10.3389/fimmu.2026.1857945
PMCID: PMC13435250

Genes

AGPAT1
BBS7
BTNL2
C4B
DDR1
EGFL8
EME1
PBX2
PPT2
PRRT1
VARS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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