Article
Application of short tandem repeats (STRs) in the preimplantation genetic diagnosis (PGD) of α-thalassemia.
Taiwanese journal of obstetrics & gynecology - 1 May 2024
Ha Vuong Vu Viet, Nguyen Phuoc-Dung, Thi Nha Nguyen, Le Thi Phuong, Minh Nguyet Dang Thi, Nguyen Manh Ha, Tran Hai Anh, Dang-Tran Nhat-Minh, Bui The-Hung, Tran Thinh Huy, Van Ta Thanh, Tran Van-Khanh
Abstract excerpt
OBJECTIVES: α-thalassemia is an autosomal recessive monogenic blood disorder, affecting up to 5% of the world's population. The occurrence rate of the disease in Vietnam varies up to up to 51.5%, with high rate of mutation carriers, of couples consisting of two carriers at risk of bearing a child with fetal Hb Bart, which can develop into hydrops fetalis syndrome, threatening the well-being of the mother and the...
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