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Detection of maternal carriers of common α-thalassemia deletions from cell-free DNA.

Scientific reports - 9 Aug 2022

Doan Phuoc-Loc, Nguyen Duy-Anh, Le Quang Thanh, Hoang Diem-Tuyet Thi, Nguyen Huu Du, Nguyen Canh Chuong, Doan Kim Phuong Thi, Tran Nhat Thang, Ha Thi Minh Thi, Trinh Thu Huong Nhat, Nguyen Van Thong, Bui Chi Thuong, Lai Ngoc-Diep Thi, Duong Thanh Hien, Mai Hai-Ly, Huynh Pham-Uyen Vinh, Huynh Thu Thanh Thi, Le Quang Vinh, Vo Thanh Binh, Dao Thi Hong-Thuy, Vo Phuong Anh, Le Duy-Khang Nguyen, Tran Ngoc Nhu Thi, Tran Quynh Nhu Thi, Van Yen-Linh Thi, Tran Huyen-Trang Thi, Nguyen Hoai Thi, Nguyen Phuong-Uyen, Do Thanh-Thuy Thi, Truong Dinh-Kiet, Tang Hung Sang, Cao Ngoc-Phuong Thi, Lam Tuan-Thanh, Tran Le Son, Nguyen Hoai-Nghia, Giang Hoa, Phan Minh-Duy

Abstract excerpt

α-Thalassemia is a common inherited blood disorder manifested mainly by the deletions of α-globin genes. In geographical areas with high carrier frequencies, screening of α-thalassemia carrier state is therefore of vital importance. This study presents a novel method for identifying female carriers of common α-thalassemia deletions using samples routinely taken for non-invasive prenatal tests for screening of...

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China
alpha-Globins
alpha-Thalassemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

beta-Thalassemia

Cell-Free Nucleic Acids

Polymerase Chain Reaction

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Identifiers

PMID: 35945425
DOI: 10.1038/s41598-022-17718-7
PMCID: PMC9363435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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