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Article

Non-invasive identification of KRAS mutation in rectal cancer using hybrid intravoxel incoherent motion and diffusion kurtosis model.

World journal of surgical oncology - 25 Nov 2025

Yuan Jie, Yao Mingrong, Wang Ziyuan, Tan Wenli, Zhang Yun, Yan Huamei, Liu Mengxiao, Liu Kun, Gong Hangjun, Zhan Songhua

Abstract excerpt

BACKGROUND AND PURPOSE: Sarcoma Viral Oncogene Homologue (KRAS) mutation status is a crucial biomarker in rectal cancer as KRAS mutations confer resistance to anti-EGFR targeted therapies and influence chemotherapy selection, affecting treatment decisions and prognosis. This study evaluates the efficacy of the hybrid intravoxel incoherent motion and diffusion kurtosis imaging (IVIM-DKI) model for non-invasive...

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Identifiers

PMID: 41291770
DOI: 10.1186/s12957-025-04097-2
PMCID: PMC12649068

Genes

KRAS
EGFR

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