Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of histidine 932 of the human mitochondrial DNA polymerase in nucleotide discrimination and inherited disease.

The Journal of biological chemistry - 29 Oct 2010

Batabyal Dipanwita, McKenzie Jessica L, Johnson Kenneth A

Abstract excerpt

The human mitochondrial DNA polymerase (pol γ) is nuclearly encoded and is solely responsible for the replication and repair of the mitochondrial genome. The progressive accumulation of mutations within the mitochondrial genome is thought to be related to aging, and mutations in the pol γ gene ar...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Pair Mismatch
Share to Catalysis
Share to Diphosphates

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Directed DNA Polymerase

Share to Genome, Mitochondrial

Share to Histidine

Share to Nucleotides

Share to Parkinson Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 20685647
DOI: 10.1074/jbc.M110.156182
PMCID: PMC2962517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20685647-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of histidine 932 of the human mitochondrial DNA polymerase in nucleotide discrimination and inherited disease.PMID 20685647Read ↗

Effect of the Y955C mutation on mitochondrial DNA polymerase nucleotide incorporation efficiency and fidelity.Semantic proximity Read ↗

An interaction network in the polymerase active site is a prerequisite for Watson-Crick base pairing in Pol γ.Semantic proximity Read ↗

The Y951N patient mutation inactivates the intramolecular switch in human mitochondrial DNA POLγSemantic proximity Read ↗

Defective Nucleotide Release by DNA Polymerase β Mutator Variant E288K Is the Basis of Its Low Fidelity.Semantic proximity Read ↗

Heterozygous p.Y955C mutation in DNA polymerase γ leads to alterations in bioenergetics, complex I subunit expression, and mtDNA replication.Semantic proximity Read ↗

DNA polymerase fidelity: from genetics toward a biochemical understanding.Semantic proximity Read ↗

Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutations.Semantic proximity Read ↗

DNA replication fidelity.Semantic proximity Read ↗

The DNA polymerase gamma Y955C disease variant associated with PEO and parkinsonism mediates the incorporation and translesion synthesis opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine.Semantic proximity Read ↗

The disease-causing mutation p.F907I reveals a novel pathogenic mechanism for POLγ-related diseases.Semantic proximity Read ↗

Characterization of the human homozygous R182W POLG2 mutation in mitochondrial DNA depletion syndrome.Semantic proximity Read ↗

Functional analysis of H. sapiens DNA polymerase gamma spacer mutation W748S with and without common variant E1143G.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.