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Deep learning for dual detection of microsatellite instability and POLE mutations in colorectal cancer histopathology

23 May 2024

Abstract excerpt

In the spectrum of colorectal tumors, microsatellite-stable (MSS) tumors with DNA polymerase ε (POLE) mutations exhibit a hypermutated profile, holding the potential to respond to immunotherapy similarly to their microsatellite-instable (MSI) counterparts. Yet, due to their rarity and the associated testing costs, systematic screening for these mutations is not commonly pursued. Notably, the histopathological...

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PMID: 38783059
DOI: 10.1038/s41698-024-00592-z

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