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Article

SARS-CoV-2 breakthrough infections enhance T cell response magnitude, breadth, and epitope repertoire.

Cell reports. Medicine - 18 Jun 2024

Tarke Alison, Ramezani-Rad Parham, Alves Pereira Neto Tertuliano, Lee Yeji, Silva-Moraes Vanessa, Goodwin Benjamin, Bloom Nathaniel, Siddiqui Leila, Avalos Liliana, Frazier April, Zhang Zeli, da Silva Antunes Ricardo, Dan Jennifer, Crotty Shane, Grifoni Alba, Sette Alessandro

Abstract excerpt

Little is known about the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or SARS2) vaccine breakthrough infections (BTIs) on the magnitude and breadth of the T cell repertoire after exposure to different variants. We studied samples from individuals who experienced symptomatic BTIs during Delta or Omicron waves. In the pre-BTI samples, 30% of the donors exhibited substantial immune memory...

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Source

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Identifiers

PMID: 38781962
DOI: 10.1016/j.xcrm.2024.101583
PMCID: PMC11228552

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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