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Article

AcMNPV P74 is cleaved at R325 and R334 by proteinases of both OB and BBMV to expose a potential fusion peptide for oral infection.

Journal of virology - 13 Jun 2024

Li Zhuorui, Zhang Nan, Zhang Tao, Wang Zhiying, Li Jiang, Wang Manli, Hu Zhihong, Wang Xi

Abstract excerpt

Baculoviruses enter insect midgut epithelial cells via a set of occlusion-derived virion (ODV) envelope proteins called per os infectivity factors (PIFs). P74 of Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV), which was the first identified PIF, is cleaved by an endogenous proteinase embedded within the occlusion body during per os infection, but the target site(s) and function of the cleavage...

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PMID: 38775478
DOI: 10.1128/jvi.00235-24
PMCID: PMC11237619

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