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Article

Susceptibility to innate immune activation in genetically mediated myocarditis.

The Journal of clinical investigation - 16 May 2024

Selgrade Daniel F, Fullenkamp Dominic E, Chychula Ivana A, Li Binjie, Dellefave-Castillo Lisa, Dubash Adi D, Ohiri Joyce, Monroe Tanner O, Blancard Malorie, Tomar Garima, Holgren Cory, Burridge Paul W, George Alfred L, Demonbreun Alexis R, Puckelwartz Megan J, George Sharon A, Efimov Igor R, Green Kathleen J, McNally Elizabeth M

Abstract excerpt

Myocarditis is clinically characterized by chest pain, arrhythmias, and heart failure, and treatment is often supportive. Mutations in DSP, a gene encoding the desmosomal protein desmoplakin, have been increasingly implicated in myocarditis. To model DSP-associated myocarditis and assess the role of innate immunity, we generated engineered heart tissues (EHTs) using human induced pluripotent stem cell-derived...

Topics

Humans
Myocarditis
Immunity, Innate
Induced Pluripotent Stem Cells
Myocytes, Cardiac
Male
Genetic Predisposition to Disease
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38768074
DOI: 10.1172/JCI180254
PMCID: PMC11213508

Genes

DSP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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