Article
DNA Methylation Near DLGAP2 May Mediate the Relationship between Family History of Type 1 Diabetes and Type 1 Diabetes Risk.
Pediatric diabetes - 1 Jan 2023
Johnson Randi K, Ireton Amanda J, Carry Patrick M, Vanderlinden Lauren A, Dong Fran, Romero Alex, Johnson David R, Ghosh Debashis, Yang Fan, Frohnert Brigitte, Yang Ivana V, Kechris Katerina, Rewers Marian, Norris Jill M
Abstract excerpt
Given the differential risk of type 1 diabetes (T1D) in offspring of affected fathers versus affected mothers and our observation that T1D cases have differential DNA methylation near the imprinted DLGAP2 gene compared to controls, we examined whether methylation near DLGAP2 mediates the association between T1D family history and T1D risk. In a nested case-control study of 87 T1D cases and 87 controls from the...
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