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In-utero exposure to maternal diabetes and DNA methylation alterations in the Next Generation birth cohort

3 Oct 2025

Abstract excerpt

INTRODUCTION: The incidence of type 2 diabetes (T2D) in youth is increasing and in-utero exposure to maternal diabetes is a known risk factor, with higher risk associated with pregestational T2D exposure compared to gestational diabetes mellitus (GDM) exposure. We hypothesize this differential risk is reflected in DNA methylation (DNAm) changes induced by differential timing of in-utero exposure to maternal...

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PMID: 41044638
DOI: 10.1186/s13148-025-01972-3

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