Generation and External Validation of a Histologic Transformation Risk Model for Patients with Follicular Lymphoma.

doi:10.1016/j.modpat.2024.100516

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Article

Generation and External Validation of a Histologic Transformation Risk Model for Patients with Follicular Lymphoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2024

Fernández-Miranda Ismael, Pedrosa Lucía, González-Rincón Julia, Espinet Blanca, de la Cruz Vicente Fátima, Climent Fina, Gómez Sagrario, Royuela Ana, Camacho Francisca I, Martín-Acosta Paloma, Yanguas-Casás Natalia, Domínguez Marina, Méndez Miriam, Colomo Luis, Salar Antonio, Horcajo Beatriz, Navarro Marta, García-Cosío Mónica, Piris-Villaespesa Miguel, Llanos Marta, García Juan F, Sequero Silvia, Mercadal Santiago, García-Hernández Sonia, Navarro Belén, Mollejo Manuela, Provencio Mariano, Sánchez-Beato Margarita

Abstract excerpt

Follicular lymphoma (FL) is the most frequent indolent lymphoma. Some patients (10%-15%) experience histologic transformation (HT) to a more aggressive lymphoma, usually diffuse large B-cell lymphoma (DLBCL). This study aimed to validate and improve a genetic risk model to predict HT at diagnosis.We collected mutational data from diagnosis biopsies of 64 FL patients. We combined them with the data from a...

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Identifiers

PMID: 38763418
DOI: 10.1016/j.modpat.2024.100516

Genes

KMT2D
TNFRSF14

Provenance

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