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Splicing diversity enhances the molecular classification of pituitary neuroendocrine tumors

11 Feb 2025

Abstract excerpt

Pituitary neuroendocrine tumors (PitNETs) are one of the most common intracranial tumors with diverse clinical manifestations. Current pathological classification systems rely primarily on histological hormone staining and transcription factors (TFs) expression. While effective in identifying three major lineages, molecular characteristics based on hormones and TFs lack sufficient resolution to fully capture the...

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PMID: 39934142
DOI: 10.1038/s41467-025-56821-x

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