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Metal exposure and breast cancer among Northern Mexican women: assessment of genetic susceptibility.

Environmental science and pollution research international - 1 Dec 2022

Gamboa-Loira Brenda, Mérida-Ortega Ángel, Rothenberg Stephen J, Cebrián Mariano E, López-Carrillo Lizbeth

Abstract excerpt

This study aims to assess breast cancer (BC) association with metals and whether polymorphisms in CYP1A1, CYP1B1, GSTM1 and GSTT1 act as confounders or as modifiers of those relationships. We performed a secondary analysis of 499 histologically confirmed BC cases and the same number of age-matched population controls. We measured urinary concentrations of 18 metals with mass spectrometry. We determined the...

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PMID: 35841505
DOI: 10.1007/s11356-022-21067-3

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