Article
Multi-omic Analyses Shed Light on The Genetic Control of High-altitude Adaptation in Sheep.
Genomics, proteomics & bioinformatics - 3 Jul 2024
Li Chao, Chen Bingchun, Langda Suo, Pu Peng, Zhu Xiaojia, Zhou Shiwei, Kalds Peter, Zhang Ke, Bhati Meenu, Leonard Alexander, Huang Shuhong, Li Ran, Cuoji Awang, Wang Xiran, Zhu Haolin, Wu Yujiang, Cuomu Renqin, Gui Ba, Li Ming, Wang Yutao, Li Yan, Fang Wenwen, Jia Ting, Pu Tianchun, Pan Xiangyu, Cai Yudong, He Chong, Wang Liming, Jiang Yu, Han Jian-Lin, Chen Yulin, Zhou Ping, Pausch Hubert, Wang Xiaolong
Abstract excerpt
Sheep were domesticated in the Fertile Crescent and then spread globally, where they have been encountering various environmental conditions. The Tibetan sheep has adapted to high altitudes on the Qinghai-Tibet Plateau over the past 3000 years. To explore genomic variants associated with high-altitude adaptation in Tibetan sheep, we analyzed Illumina short-reads of 994 whole genomes representing ∼ 60 sheep...
Topics
- Animals
- Altitude
- Sheep
- Haplotypes
- Adaptation, Physiological
- Transcriptome
- Polymorphism, Single Nucleotide
- Proteomics
- beta-Globins