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Article

The Search for and Functional Analysis of Genetic Variants in microRNA-Binding Sites using Massively Parallel Reporter Assay.

Bulletin of experimental biology and medicine - 1 Mar 2024

Rykova E Yu, Ershov N I, Degtyareva A O, Bryzgalov L O, Lushnikova E L

Abstract excerpt

A large-scale search for the genetic variants with a bias in the representation of alleles in transcriptome data (AE SNPs) and the binding sites in microRNA 3'-UTRs was performed and their functional significance was assessed using massively parallel reporter assay (MPRA). Of the 629,559 associated "SNP-gene" pairs (eQTLs) discovered in the human liver tissue according to the GTEx Analysis V8 data, 4394...

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PMID: 38724816
DOI: 10.1007/s10517-024-06074-3

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