Quality of life in patients with BRAF-mutant melanoma receiving the combination encorafenib plus binimetinib: Results from a multicentre, open-label, randomised, phase III study (COLUMBUS).

doi:10.1016/j.ejca.2021.04.028

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Article

Quality of life in patients with BRAF-mutant melanoma receiving the combination encorafenib plus binimetinib: Results from a multicentre, open-label, randomised, phase III study (COLUMBUS).

European journal of cancer (Oxford, England : 1990) - 1 Jul 2021

Gogas Helen, Dummer Reinhard, Ascierto Paolo A, Arance Ana, Mandalà Mario, Liszkay Gabriella, Garbe Claus, Schadendorf Dirk, Krajsová Ivana, Gutzmer Ralf, Sileni Vanna Chiarion, Dutriaux Caroline, Yamazaki Naoya, Loquai Carmen, Queirolo Paola, Jan de Willem Groot, Sellier Abir Tadmouri, Suissa Jeanne, Murris Juliette, Gollerkeri Ashwin, Robert Caroline, Flaherty Keith T

Abstract excerpt

BACKGROUND: In COLUMBUS, treatment with encorafenib plus binimetinib in patients with advanced BRAF-mutant melanoma showed improved progression-free and overall survival with favourable tolerability compared to vemurafenib treatment. Here, results on health-related quality of life (HRQoL) are presented. METHODS: COLUMBUS was a two-part, open-label, randomised, phase III study in patients with BRAF-mutant...

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PMID: 34091420
DOI: 10.1016/j.ejca.2021.04.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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