Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Decoding polygenic diseases: advances in noncoding variant prioritization and validation.

Trends in cell biology - 1 Jun 2024

Chin Iris M, Gardell Zachary A, Corces M Ryan

Abstract excerpt

Genome-wide association studies (GWASs) provide a key foundation for elucidating the genetic underpinnings of common polygenic diseases. However, these studies have limitations in their ability to assign causality to particular genetic variants, especially those residing in the noncoding genome. Over the past decade, technological and methodological advances in both analytical and empirical prioritization of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease
Share to Genetic Variation
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Multifactorial Inheritance

Source

Open in PubMed Open full text

Identifiers

PMID: 38719704
DOI: 10.1016/j.tcb.2024.03.005
PMCID: PMC12176383

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decoding polygenic diseases: advances in noncoding variant prioritization and validation.PMID 38719704Read ↗

Functional characterization of human genomic variation linked to polygenic diseases.Semantic proximity Read ↗

Challenges and progress in interpretation of non-coding genetic variants associated with human disease.Semantic proximity Read ↗

The emerging field of polygenic risk scores and perspective for use in clinical care.Semantic proximity Read ↗

Progress and promise in understanding the genetic basis of common diseases.Semantic proximity Read ↗

Interpreting noncoding genetic variation in complex traits and human disease.Semantic proximity Read ↗

A guide to performing Polygenic Risk Score analysesSemantic proximity Read ↗

A perspective on genetic and polygenic risk scores-advances and limitations and overview of associated tools.Semantic proximity Read ↗

Clinical use of polygenic risk scores: current status, barriers and future directions.Semantic proximity Read ↗

Genetic associations of protein-coding variants in human diseaseSemantic proximity Read ↗

Demystifying non-coding GWAS variants: an overview of computational tools and methods.Semantic proximity Read ↗

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.Semantic proximity Read ↗

Genetic associations of protein-coding variants in human disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.