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Article

Global Proteomic Analysis Reveals Alterations in Differentially Expressed Proteins between Cardiopathic Lamin A/C Mutations.

Journal of proteome research - 7 Jun 2024

Anderson Corey L, Brown Kyle A, North Ryan J, Walters Janay K, Kaska Sara T, Wolff Mathew R, Kamp Timothy J, Ge Ying, Eckhardt Lee L

Abstract excerpt

Lamin A/C (LMNA) is an important component of nuclear lamina. Mutations cause arrhythmia, heart failure, and sudden cardiac death. While LMNA-associated cardiomyopathy typically has an aggressive course that responds poorly to conventional heart failure therapies, there is variability in severity and age of penetrance between and even within specific mutations, which is poorly understood at the cellular level....

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Identifiers

PMID: 38718259
DOI: 10.1021/acs.jproteome.3c00853
PMCID: PMC11218822

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