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Article

Identification of 2 Novel Subtypes of Hepatitis C Virus Genotype 8 and a Potential New Genotype Successfully Treated With Direct Acting Antivirals.

The Journal of infectious diseases - 16 Dec 2024

Mbisa Jean L, Lapp Zena, Bibby David F, Phillips Laura T, Manso Carmen F, Packer Simon, Simmons Ruth, Harris Kathryn, Mohan Jaiganesh, Chinnappan Lalitha, Leitner Thomas, Bradshaw Daniel

Abstract excerpt

BACKGROUND: Hepatitis C virus (HCV) has high genetic diversity and is classified into 8 genotypes and >90 subtypes, with some endemic to specific world regions. This could compromise direct-acting antiviral efficacy and global HCV elimination. METHODS: We characterized HCV subtypes "rare" in the United Kingdom (non-1a/1b/2b/3a/4d) by means of whole-genome sequencing via a national surveillance program. Genetic...

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Identifiers

PMID: 38717937
DOI: 10.1093/infdis/jiae253
PMCID: PMC11646602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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