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Backbone and methyl side-chain resonance assignments of the single chain Fab fragment of trastuzumab

8 May 2024

Abstract excerpt

Trastuzumab is a therapeutic monoclonal antibody developed to target human epidermal growth factor receptor 2 (HER2) present at higher levels in early cancers. Here we report the near complete resonance assignment of trastuzumab-scFab fragment backbone and the methyl groups of isoleucine, leucine and valine residues, as well as their stereo-assignments. The antibody fragment was produced using a single chain...

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PMID: 38717571
DOI: 10.1007/s12104-024-10177-3

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