Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FLT4 causes developmental disorders of the cardiovascular and lymphovascular systems via pleiotropic molecular mechanisms.

Cardiovascular research - 2 Sept 2024

Monaghan Richard M, Naylor Richard W, Flatman Daisy, Kasher Paul R, Williams Simon G, Keavney Bernard D

Abstract excerpt

AIMS: Rare, deleterious genetic variants in FLT4 are associated with Tetralogy of Fallot (TOF), the most common cyanotic congenital heart disease. The distinct genetic variants in FLT4 are also an established cause of Milroy disease, the most prevalent form of primary hereditary lymphoedema. The phenotypic features of these two conditions are non-overlapping, implying pleiotropic cellular mechanisms during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum
Share to Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Human Umbilical Vein Endothelial Cells

Share to Lymphedema

Share to Tetralogy of Fallot

Share to Vascular Endothelial Growth Factor Receptor-3

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 38713105
DOI: 10.1093/cvr/cvae104
PMCID: PMC11368125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FLT4 causes developmental disorders of the cardiovascular and lymphovascular systems via pleiotropic molecular mechanisms.PMID 38713105Read ↗

The physiological and pathological functions of VEGFR3 in cardiac and lymphatic development and related diseases.Semantic proximity Read ↗

Clinical Genetic Risk Variants Inform a Functional Protein Interaction Network for Tetralogy of Fallot.Semantic proximity Read ↗

Clinical genetic risk variants inform a functional protein interaction network for tetralogy of FallotSemantic proximity Read ↗

Rare variants in KDR, encoding VEGF Receptor 2, are associated with tetralogy of Fallot.Semantic proximity Read ↗

Whole Exome Sequencing Reveals the Major Genetic Contributors to Nonsyndromic Tetralogy of FallotSemantic proximity Read ↗

Haploinsufficiency of vascular endothelial growth factor related signaling genes is associated with tetralogy of FallotSemantic proximity Read ↗

Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedemaSemantic proximity Read ↗

Genes and Pathways Implicated in Tetralogy of Fallot Revealed by Ultra-Rare Variant Burden Analysis in 231 Genome SequencesSemantic proximity Read ↗

Noonan syndrome-associated biallelic LZTR1 mutations cause cardiac hypertrophy and vascular malformations in zebrafish.Semantic proximity Read ↗

Sequencing of a Chinese tetralogy of Fallot cohort reveals clustering mutations in myogenic heart progenitors.Semantic proximity Read ↗

Loss of ERG function causes lymphatic vessel malformations and primary lymphoedemaSemantic proximity Read ↗

Identification of a Novel FLT4 c.3028A>C Variant Associated With Milroy Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.