Transcriptomic Signatures of Progression to Tuberculosis Disease Among Close Contacts in Brazil

Abstract excerpt

BACKGROUND: Approximately 5% of people infected with Mycobacterium tuberculosis progress to tuberculosis (TB) disease without preventive therapy. There is a need for a prognostic test to identify those at highest risk of incident TB so that therapy can be targeted. We evaluated host blood transcriptomic signatures for progression to TB disease. METHODS: Close contacts (≥4 hours of exposure per week) of adult...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Mycobacterium research and diagnosis
• Share to Pneumocystis jirovecii pneumonia detection and treatment
• Share to Tuberculosis Research and Epidemiology