Article
Quality-Assured Analysis of PIK3CA Mutations in Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer Tissue.
The Journal of molecular diagnostics : JMD - 1 Jul 2024
Schmidt Carolin, Stöhr Robert, Dimitrova Lora, Beckmann Matthias W, Rübner Matthias, Fasching Peter A, Denkert Carsten, Lehmann Ulrich, Vollbrecht Claudia, Haller Florian, Hartmann Arndt, Erber Ramona
Abstract excerpt
In precision oncology, reliable testing of predictive molecular biomarkers is a prerequisite for optimal patient treatment. Interlaboratory comparisons are a crucial tool to verify diagnostic performance and reproducibility of one's approach. Herein is described the design and results of the first recurrent, internationally performed PIK3CA (phosphatidylinositol-4,5-bisphosphate 3 kinase catalytic subunit α)...
Topics
- Humans
- Class I Phosphatidylinositol 3-Kinases
- Breast Neoplasms
- Female
- Mutation
- Receptor, ErbB-2
- Biomarkers, Tumor
- Receptors, Estrogen
- Reproducibility of Results