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Article

Mutation of the ALS-/FTD-Associated RNA-Binding Protein FUS Affects Axonal Development.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Jul 2024

van Tartwijk Francesca W, Wunderlich Lucia C S, Mela Ioanna, Makarchuk Stanislaw, Jakobs Maximilian A H, Qamar Seema, Franze Kristian, Kaminski Schierle Gabriele S, St George-Hyslop Peter H, Lin Julie Qiaojin, Holt Christine E, Kaminski Clemens F

Abstract excerpt

Aberrant condensation and localization of the RNA-binding protein (RBP) fused in sarcoma (FUS) occur in variants of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Changes in RBP function are commonly associated with changes in axonal cytoskeletal organization and branching in neurodevelopmental disorders. Here, we asked whether branching defects also occur in vivo in a model of...

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Identifiers

PMID: 38692734
DOI: 10.1523/JNEUROSCI.2148-23.2024
PMCID: PMC7616130

Genes

FUS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutation of the ALS-/FTD-Associated RNA-Binding Protein FUS Affects Axonal Development.PMID 38692734Read ↗

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