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Article

Case report: Temozolomide induced hypermutation indicates an unfavorable response to immunotherapy in patient with gliomas.

Frontiers in immunology - 1 Jan 2024

Liu Jiapeng, Hu Shuli, Jiang Haihui, Cui Yong

Abstract excerpt

Background: Temozolomide (TMZ) is a key component in the treatment of gliomas. Hypermutation induced by TMZ can be encountered in routine clinical practice, and its significance is progressively gaining recognition. However, the relationship between TMZ-induced hypermutation and the immunologic response remains controversial. Case presentation: We present the case of a 38-year-old male patient who underwent five...

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Identifiers

PMID: 38690285
DOI: 10.3389/fimmu.2024.1369972
PMCID: PMC11059094

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