An integrated analysis of MEN1 reveals its associations with clinical outcomes, cellular pathways, and the immune microenvironment.

doi:10.1186/s12957-026-04460-x

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Article

An integrated analysis of MEN1 reveals its associations with clinical outcomes, cellular pathways, and the immune microenvironment.

World journal of surgical oncology - 17 Jun 2026

Li Hao, Gong Xinyu, Yao Yanwei, Bi Ping, Li Qiang, Wang Xiaoru, Peng Jian

Abstract excerpt

The menin protein, encoded by the Multiple Endocrine Neoplasia Type 1 (MEN1) gene, serves as a critical regulator of cellular processes in human cancers. While menin-targeted therapies are undergoing clinical investigation, a comprehensive pan-cancer analysis of MEN1's diagnostic, prognostic, and immunomodulatory roles remain lacking. Here, we systematically evaluated MEN1 expression patterns and clinical...

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Identifiers

PMID: 42310775
DOI: 10.1186/s12957-026-04460-x
PMCID: PMC13520262

Genes

MEN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.