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Article

Dynamic diversity of SARS-CoV-2 genetic mutations in a lung transplantation patient with persistent COVID-19.

Nature communications - 29 Apr 2024

Igari Hidetoshi, Sakao Seiichiro, Ishige Takayuki, Saito Kengo, Murata Shota, Yahaba Misuzu, Taniguchi Toshibumi, Suganami Akiko, Matsushita Kazuyuki, Tamura Yutaka, Suzuki Takuji, Ido Eiji

Abstract excerpt

Numerous SARS-CoV-2 variant strains with altered characteristics have emerged since the onset of the COVID-19 pandemic. Remdesivir (RDV), a ribonucleotide analogue inhibitor of viral RNA polymerase, has become a valuable therapeutic agent. However, immunosuppressed hosts may respond inadequately to RDV and develop chronic persistent infections. A patient with respiratory failure caused by interstitial pneumonia,...

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Identifiers

PMID: 38684722
DOI: 10.1038/s41467-024-47941-x
PMCID: PMC11058237

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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