Association of the IFNG +874T/A Polymorphism with Symptomatic COVID-19 Susceptibility.

doi:10.3390/v16040650

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Article

Association of the IFNG +874T/A Polymorphism with Symptomatic COVID-19 Susceptibility.

Viruses - 22 Apr 2024

Sarges Kevin Matheus Lima de, Póvoa da Costa Flávia, Santos Erika Ferreira Dos, Cantanhede Marcos Henrique Damasceno, da Silva Rosilene, Veríssimo Adriana de Oliveira Lameira, Viana Maria de Nazaré do Socorro de Almeida, Rodrigues Fabíola Brasil Barbosa, Leite Mauro de Meira, Torres Maria Karoliny da Silva, Bentes da Silva Christiane, Brito Mioni Thieli Figueiredo Magalhães de, Silva Andréa Luciana Soares da, Henriques Daniele Freitas, Vallinoto Izaura Maria Vieira Cayres, Viana Giselle Maria Rachid, Queiroz Maria Alice Freitas, Vallinoto Antonio Carlos Rosário, Santos Eduardo José Melo Dos

Abstract excerpt

Tumor necrosis factor (TNF) and interferon-gamma (IFNγ) are important inflammatory mediators in the development of cytokine storm syndrome (CSS). Single nucleotide polymorphisms (SNPs) regulate the expression of these cytokines, making host genetics a key factor in the prognosis of COVID-19. In t...

Topics

Female
Humans
Male
Alleles
COVID-19
Cytokine Release Syndrome
Gene Frequency
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Interferon-gamma

Polymorphism, Single Nucleotide

SARS-CoV-2

Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 38675991
DOI: 10.3390/v16040650
PMCID: PMC11053931

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-38675991-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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