Serotonin Transporter (SLC6A4) and FK506-Binding Protein 5 (FKBP5) Genotype and Methylation Relationships with Response to Meditation in Veterans with PTSD.

doi:10.1007/s12035-024-04096-6

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Article

Serotonin Transporter (SLC6A4) and FK506-Binding Protein 5 (FKBP5) Genotype and Methylation Relationships with Response to Meditation in Veterans with PTSD.

Molecular neurobiology - 1 Nov 2024

Lee Adam, Thuras Paul, Baller Joshua, Jiao Chuan, Guo Bin, Erbes Christopher R, Polusny Melissa A, Liu Chunyu, Wu Baolin, Lim Kelvin O, Bishop Jeffrey R

Abstract excerpt

Meditation-based interventions are novel and effective non-pharmacologic treatments for veterans with PTSD. We examined relationships between treatment response, early life trauma exposure, DNA polymorphisms, and methylation in the serotonin transporter (SLC6A4) and FK506-binding protein 5 (FKBP5...

Topics

Adult
Female
Humans
Male
Middle Aged
DNA Methylation
Genotype
Meditation
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Serotonin Plasma Membrane Transport Proteins
Stress Disorders, Post-Traumatic
Tacrolimus Binding Proteins

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Treatment Outcome

Veterans

Source

Open in PubMed

Identifiers

PMID: 38671329
DOI: 10.1007/s12035-024-04096-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-38671329-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.