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Unraveling the Pathogenetic Mechanisms Underlying the Association between Specific Mitochondrial DNA Haplogroups and Parkinson’s Disease

17 Apr 2024

Abstract excerpt

Variants of mitochondrial DNA (mtDNA) have been identified as risk factors for the development of Parkinson’s disease (PD). However, the underlying pathogenetic mechanisms remain unclear. Cybrid models carrying various genotypes of mtDNA variants were tested for resistance to PD-simulating MPP+ treatment. The most resistant line was selected for transcriptome profiling, revealing specific genes potentially...

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PMID: 38667309
DOI: 10.3390/cells13080694

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