Article

Artificial intelligence as a ploy to delve into the intricate relationship between genetics and mitochondria in MASLD patients

2024-06-04

Abstract excerpt

<h4>Background and Aims</h4> Mitochondrial (mt-) dysfunction is a hallmark of progressive MASLD. MtDNA copy number (mtDNA-CN) and cell-free circulating mtDNA (ccf-mtDNA), which reflect mt-mass and mt-dysfunction, respectively, are gaining attention as non-invasive disease biomarkers. We previously demonstrated that PNPLA3 / MBOAT7 / TM6SF2 deficiency in HepG2 cells increased mt-mass, mtDNA-CN and ccf-mtDNA. Th...

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Literature Corpus work: 8a557696-4566-5477-a409-7c2134923eb4
DOI: 10.1101/2024.06.03.597155

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