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Article

Generation of a MYH6 (c.4034T > C) mutant human embryonic stem cell line via CRISPR base editing.

Stem cell research - 1 Dec 2024

Jiang Xiaodong, Liu Qiying, Yang Lihui, Zhang Xiaohong, Gao Jiaqi, Jiang Youxu

Abstract excerpt

The MYH6 gene encodes α-myosin heavy chain in the adult human heart. MYH6 c.4034T > C (p.Leu1345Pro) mutation in MYH6 gene have been reported in patients with hypertrophic cardiomyopathy (HCM), but its causal role in HCM is less certain and has not been established unambiguously. Here, we generated a MYH6 (c.4034T > C) mutant human embryonic stem cell line (WAe009-A-1D) based on the CRISPR adenine base editing...

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PMID: 39541768
DOI: 10.1016/j.scr.2024.103610

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