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Targeted genotyping for recurring variants in cancer susceptibility genes in non-Ashkenazi Jewish patients with breast cancer diagnosed ≥50 years.

Cancer - 15 Aug 2024

Bernstein-Molho Rinat, Shhada Narmeen Abu, Laitman Yael, Netzer Iris, Shoval Shelley, Friedman Eitan

Abstract excerpt

PURPOSE: Several recurring pathogenic variants (PVs) in BRCA1/BRCA2 and additional cancer susceptibility genes are described in the ethnically diverse Israeli population. Since 2019, testing for these recurring PVs is reimbursed unselectively for all patients with breast cancer (BC) in Israel. The aim was to evaluate the yield of genotyping for these PVs in non-Ashkenazi Jewish (AJ) patients with BC diagnosed...

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PMID: 38630906
DOI: 10.1002/cncr.35329

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