Article
Multiplex fluorescent amplification-refractory mutation system PCR method for the detection of 10 genetic defects in Holstein cattle and its comparison with the KASP genotyping assay.
Animal genetics - 1 Jun 2024
Khan Md Yousuf Ali, Dai Dongmei, Su Xin, Tian Jia, Zhou Jiamin, Ma Liqin, Wang Yachun, Wen Wan, Zhang Yi
Abstract excerpt
The common deleterious genetic defects in Holstein cattle include haplotypes 1-6 (HH1-HH6), haplotypes for cholesterol deficiency (HCD), bovine leukocyte adhesion deficiency (BLAD), complex vertebral malformation (CVM) and brachyspina syndrome (BS). Recessive inheritance patterns of these genetic defects permit the carriers to function normally, but homozygous recessive genotypes cause embryo loss or neonatal...
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