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Article

A new test for trait mean and variance detects unreported loci for blood-pressure variation.

American journal of human genetics - 2 May 2024

Breeyear Joseph H, Mautz Brian S, Keaton Jacob M, Hellwege Jacklyn N, Torstenson Eric S, Liang Jingjing, Bray Michael J, Giri Ayush, Warren Helen R, Munroe Patricia B, Velez Edwards Digna R, Zhu Xiaofeng, Li Chun, Edwards Todd L

Abstract excerpt

Variability in quantitative traits has clinical, ecological, and evolutionary significance. Most genetic variants identified for complex quantitative traits have only a detectable effect on the mean of trait. We have developed the mean-variance test (MVtest) to simultaneously model the mean and log-variance of a quantitative trait as functions of genotypes and covariates by using estimating equations. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38614075
DOI: 10.1016/j.ajhg.2024.03.014
PMCID: PMC11080606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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