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Article

Proteogenomic Characterization Reveals Estrogen Signaling as a Target for Never-Smoker Lung Adenocarcinoma Patients without EGFR or ALK Alterations.

Cancer research - 2 May 2024

Park Seung-Jin, Ju Shinyeong, Goh Sung-Ho, Yoon Byoung-Ha, Park Jong-Lyul, Kim Jeong-Hwan, Lee Seonjeong, Lee Sang-Jin, Kwon Yumi, Lee Wonyeop, Park Kyung Chan, Lee Geon Kook, Park Seog Yun, Kim Sunshin, Kim Seon-Young, Han Ji-Youn, Lee Cheolju

Abstract excerpt

Never-smoker lung adenocarcinoma (NSLA) is prevalent in Asian populations, particularly in women. EGFR mutations and anaplastic lymphoma kinase (ALK) fusions are major genetic alterations observed in NSLA, and NSLA with these alterations have been well studied and can be treated with targeted therapies. To provide insights into the molecular profile of NSLA without EGFR and ALK alterations (NENA), we selected 141...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38607364
DOI: 10.1158/0008-5472.CAN-23-1551

Genes

ALK
EGFR
STK11
ERBB2
KRAS
LLGL2
ROS1
SETD2
ST14
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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